Nanomaterials Versus The Microbial Compounds With Wound Healing Property

Age and diabetes related slow-healing or chronic wounds may result in morbidity mortality through persistent biofilms infections prolonged inflammatory phase. Nano-materials [metal/metal oxide NPs (39%), lipid vehicles (21%), polymer (19%), ceramic nanoparticles (NPs) (14%), carbon nanomaterials (NMs) (7%)] can be introduced as a possible next-generation therapy because of either their intrinsic wound healing activity via carrying bioactive compounds including, antibiotics, antioxidants, growth factor stem cell. The have been shown to implicate all four stages including hemostasis (polymer NPs, nanoceria-6.1%), inflammation (liposome/vesicles/solid NPs/polymer NPs/ceramic NPs/silver NPs/gold NPs/nanoceria/fullerenes/carbon-based NPs-32.7%), proliferation (vesicles/liposome/solid NPs/iron NPs/copper NPs/self-assembling elastin-like NPs/nanoceria/micelle/dendrimers/polymer NPs-57.1%), remodeling (iron NPs/nanoceria-4.1%). Natural from alkaloids, flavonoids, retinoids, volatile oil, terpenes, carotenoids, polyphenolic with proven antioxidant, anti-inflammatory, immunomodulatory, antimicrobial characteristics are also well known for potential accelerate the process. In current paper, we survey properties microbial improving process scar healing. Finally, review biocompounds incorporation nano-material perspective designate more effective multivalent natural nano-based drugs.